The effects of propylthiouracil on small intestine of mice: a light and electron microscobical study

Abstract

In this study, the effect of propylthiouracil on epithelial cells of the small intestine is examined by histologicaland cytological methods. As a result of histologic analyses an increase in PAS positive reaction was observed inthe intestinal epithelium of the experimental group given PTU for 1 month. As a result of cytologic examination,administration of PTU for 1 month to rats induced marked ultrastructural changes in the small intestinalepithelium. As a result, we can conclude that PTU causes significant structural changes and stimulates itssynthesis and secretion functions in the small intestinal epithelium