Estimation of serum copper, manganese, selenium, and Zinc in hypothyroidism patients

Abstract

Decreased thyroid hormone synthesis and low levels of circulating thyroid hormones result in biochemicaland/or clinical hypothyroidism. Deficiency of thyroid hormones causes many metabolic processes to slow down.The maintenance of optimal health requires an adequate supply of carbohydrates, proteins and lipids, andmacronutrients, micronutrients, and trace elements. In this work, the serum content of the trace elements; Zn, Cu,Mn, and Se in hypothyroidism patients was determined and compared to that of normal subjects. Seventy threehypothyroid patients and fifty normal healthy control persons participated in this study. Serum zinc and copperwere determined using flame atomic absorption spectrophotometer, while determination of manganese andselenium were done using flameless atomic absorption spectrophotometer. The results showed that serum zincand selenium level of hypothyroidism patients are significantly lower (p0.05) in serum copper. The resultsof this work as discussed indicate, the role of these trace elements in many metabolic process either as essentialnutrients or as cofactors for different enzymes contributed directly or indirectly to the hypothyroidism.Consequently, the results of this study suggest that the metabolism of zinc, manganese, and selenium is abnormalin hypothyroidism disease.