Benzoik asit halkalı yeni hibrit kalkonların sentezi ve biyolojik aktiviteleri

Synthesis and biological activities of new hybrid chalcones with benzoic acid ring

Özet

4-formilbenzoik asit ile çeşitli ketonların Claisen–Schmidt kondensasyonuyla bir dizi E-4-(3-okso-3-(sübstitüe)prop-1-en- 1-il)benzoik asit türevleri (1-5) sentezlenmiştir. Sentezlenen bileşiklerin (1-5), antikolinesteraz (AChE ve BChE), tirosinaz ve üreaz inhibisyon aktiviteleri incelendi. Antikolinesteraz inhibisyon aktivitesinde AChE enzimine karşı en aktif bileşiğin, bileşik 1 olduğu tespit edilmiştir. Bileşik 4, tirosinaz inhibisyon aktivitesinde en aktif bileşik iken bileşik 3, üreaz inhibisyon aktivitesinde en aktif bileşiktir.

Abstract

A series of E-4-(3-oxo-3-(substituted)prop-1-en-1-yl)benzoic acid derivatives (1-5) were synthesized by the Claisen-Schmidt condensation of various ketones with 4-formylbenzoic acid. The anticholinesterase (AChE and BChE), tyrosinase, and urease inhibition activities of the synthesized compounds (1-5) were examined. It was found that the most active compound against AChE enzyme in anticholinesterase inhibition activity was compound 1. Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.