Investigation of renal histopathological changes due to HIV-RT inhibitor 2-phenowymethyl-5-chlorobenzimidazole administration in rats

Abstract

2-phenoxymethyl-5-chlorobenzimidazole is a newly synthesized Human Immunodeficiency Virus- Reverse Transcriptase (HIV-RT) inhibitor. In a previous study it was found that this chemical entity was partially secreted and possibly metabolized in the liver of rats depending on histological data. This study was aimed to investigate the histological changes in the kidneys of rats receiving 2-phenoxymethyl-5-chlorobenzimidazole intramuscularly dissolved in dimethylsulfoxide (DMSO) injected as a single and consecutive 7 doses (5mg/kg) within 14 days with respect to the control group without any intervention. Additionally control experiments to observe the possible effects of the solvent DMSO were also designed. The results indicated that; there is minor toxicity in the renal tubular epithelia disrupting the reabsorbtion and secretion functions of the tubules as both DMSO and 2-phenoxymethyl-5-chlorobenzimidazole are hydrophobic and have capacity to distract membranous fractions of the cells.