Malondialdehyde as an indicator of ischaemic heart disease

Abstract

Lipids are the most involved class of molecules among the many targets of oxidative stress. Lipid oxidation produces a number of secondary products. The principal and most studied product of polyunsaturated fatty acid peroxidation is malondialdehyde (MDA). Beside being a highly toxic molecule, malondialdehyde is also considered as a marker of lipid peroxidation. This study was intended to determine the lipid endoperoxide levels of some Turkish patients with ischaemic heart disease findings at coroner angiography and verify whether malondialdehyde could be an indicator of ischaemic heart disease. For this purpose lipid peroxide levels of the control and test groups were measured with spectrophotometric method which is based on the reaction between malondialdehyde and thiobarbituric acid. Statistical analysis of our results revealed a significant difference between the mean serum lipid peroxide levels of the patiens and the control group being 3.74±0.44 nmol/ml vs 2.72±0.53 nmol/ml respectively, and p=0.258. According to these results we concluded that presence of MDA in serum at certain levels may predict the insurgence of vascular pathologies.