Injectable polyethylene glycol terminated poly(propylene fumarate)/acrylamide biodegradable materials for cardiac applications

Abstract

Injectable and biodegradable hydrogel material based on polyethylene glycol terminated poly(propylene fumarate)(PEG-PPF-PEG)/ acrylamide have been developed and evaluated for cardiac applications. The present PEG-PPF-PEG resin undergoes fast setting with acrylamide with low exothermic temperature and mechanical properties equivalent to that of cardiac tissue. The chemically cross linked hydrogels undergo swelling in Ringer’s solution prior to degradation. The present material are non cytotoxic to L-929 fibroblast and compatible with the cardiac fibroblast cells. Adhesion and proliferation of cardiac fibroblast cells has been appreciably good which is due to surface reorganisation and generation of synergistic hydrophilic-hydrophobic surface.