Microwave-assisted synthesis and characterization of poly(1-Azabicyclo[4.2.0]octane) and its water-soluble derivatives

Abstract

In this study we offer a new method to synthesize positively charged poly(1-Azabicyclo[4.2.0]octane)-common name is polyconidine- and its water-soluble polyampholyte derivative synthesized with bromoacetic acid using microwave irradiation as a model carrier system for biological macromolecules like peptides, proteins and etc. 1-Azabicyclo[4.2.0]octane containing unsubstituted four-membered azetidine ring was synthesized using microwaveassisted synthesis method and used as monomer in cationic ring-opening polymerization. Different alkyl halide derivatives were used as initiators to start polymerization. Microwave-assisted synthesis of polyconidine derivatives was carried out by bromoacetic acid using microwave irradiation. Characterization of polyconidine and its derivatives was achieved by size-exclusion chromatography (SEC) with on line quadruple detection system, ATR FT-IR and UV Spectroscopy.