CK-MB aktivite ölçümünde yalancı pozitifliğin değerlendirilmesi

Abstract

CK isoenzymes provide more spesific information about injured tissue because of their tissue distribution. CK-linked immunuglobulins are recognized as macro CK because of their large molecular size. Clinical importance of macro CK lies in its potential to create confusion during the investigation of possible myocardial injury. Although the better approach is to measure CK-MB mass by using immunometric assay with monoclonal antibodies for the M or B subunit, CK-MB mass method is also not free of interference with CK-BB, CK-MM, mitochondrial and macro CK. In this report, since we determined false positivity in two cases that applied to our department, we aimed to reveal particular points that will be taken into consideration in connection with interpretation of CK-MB activity assay.