Faktör V leiden mutasyonuna bağlı bacak ülserleri

Abstract

Venous leg ulcers constitute 70 % of all leg ulcers which is a serious consequence of postthrombotic syndrome. Immobilisation, surgery, trauma, pregnancy, oral contraceptive drugs and some coagulation defects have been reported to be risk factors for venous thrombosis. Activated protein C resistance is the most frequent cause of hereditary thrombophilia which is mostly associated with a point mutation in factor V protein. Risk of venous thrombosis is substantially increased in patients with factor V Leiden mutation.Herein we report two cases with factor V Leiden mutation which responded dramatically to oral anticoagulation therapy.