Dergiler / GORM:Gynecology Obstetrics & Reproductive Medicine / 1998 / Cilt: 4 - Sayı: 1
Jinekolojik tümörlerde serum Ca 15-3 düzeylerinin predüktif önemi
- Sayfa
- 40–44
- DOI
- —
Özet
OBJECTIVE: To investigate the predictive value of CA 15-3 and CA 125 in the management of gynecologic malignancies MATERIALS AND METHODS: Serum levels of CA 15-3 and CA 125 were measured in 55 patients with a gynecologic neoplasm of which 35 were malignant (13 epithelial ovarian cancer, 11 cervix cancer, 10 endometrium cancer, and 1 vulvar cancer) and 20 were benign. Cut -off values for CA 15-3 was taken as 30U/mL. and 60U/mL. ; for CA 125 it was taken as 35U/mL. and 50U/mL . Sensitivity, specificity, positive and negative predictive values for each of the cut-off value are calculated. RESULTS: The mean values of CA 15-3 were 41.3 ± 8.4 and 20.2 ± 3.5 for malignant and benign tumors, respectively. Serum CA 15-3 and CA 125 values of malignant ovarian neoplasms were higher than those of the benign group, and the difference was statistically significant (P
Abstract
OBJECTIVE: To investigate the predictive value of CA 15-3 and CA 125 in the management of gynecologic malignancies MATERIALS AND METHODS: Serum levels of CA 15-3 and CA 125 were measured in 55 patients with a gynecologic neoplasm of which 35 were malignant (13 epithelial ovarian cancer, 11 cervix cancer, 10 endometrium cancer, and 1 vulvar cancer) and 20 were benign. Cut -off values for CA 15-3 was taken as 30U/mL. and 60U/mL. ; for CA 125 it was taken as 35U/mL. and 50U/mL . Sensitivity, specificity, positive and negative predictive values for each of the cut-off value are calculated. RESULTS: The mean values of CA 15-3 were 41.3 ± 8.4 and 20.2 ± 3.5 for malignant and benign tumors, respectively. Serum CA 15-3 and CA 125 values of malignant ovarian neoplasms were higher than those of the benign group, and the difference was statistically significant (P