Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study

Abstract

In this study, we investigated that the histopathological changes of rat kidney and liver tissuesafter cisplatin administration and potential beneficial effects of morin and hesperidinadministration. Wistar rats were randomly divided in 7 groups: control, morin (M), hesperidin(H), cisplatin (CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H),cisplatin+morin+hesperidin (CP+M+H). Kidney and liver tissues were collected at the end ofthe experiment and were evaluated histopathological changes. Various histopathologicalchanges in kidney and liver tissues of cisplatin-induced group were revealed. However, pre- andco-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxicchanges in cisplatin-induced groups.