Synthesis of New Ligands Containing Azomethine Group and Investigation of Antioxidant, Antiurease Activities

Abstract

A series of Schiff base ligands containing 1,2,4-triazole ring were obtained by the addition ofaldehydes to the amino compound under mild conditions in 80–82% yields. A reduction of theseligands with sodium borohydride resulted in Schiff base reduction products. New ligands wereinvestigated for their antioxidant activities such as DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS(2,2’-azino-bis (3-ethylbenzo-thizoline-6-sulphonic acid) diammonium salt) radical scavengingand reducing power. 1H and 13C-NMR spectra (δ, ppm) were observed on a Varian Mercury 200MHz spectrophotometer as standard substance using tetramethylsilane Match constants (Jvalues) were given as Hertz. NMR coefficients are truncated as follows: s=singlet, d=dublet,t=triplet, m=multiplet signal. Combustion analysis was performed on a Carlo Erba 1106 elementalanalyzer. All the compounds gave C, H, and N analysis results within ±0.6 % of the theoreticalvalues. The IR spectra (υ, cm−1) were viewed with a Perkin-Elmer 1600 FTIR spectrometer inKBr pellets.