The role of hyperosmolality and hemodynamic alterations in radiocontrast nephropathy

Abstract

In the present study we determined the hemodynamic parameters that are formed in rats with reduced renal mass (70-75 %) when radiocontrast material, hypertonic and isotonic solutions are infused. The rats from all three groups had statistically the same indirect blood pressures prior to nephrectomy and. after the nephrectomy the indirect blood pressure levels increased to the same level in all three groups. For all three groups the pulse rates exhibited no change after the nephrectomy. The direct blood pressure values obtained from the transducer in the A. Femoralis were same for all three groups. During the infusion the direct systolic and diastolic blood pressures of the rats that received radiocontrast material and 4.5 % NaCl exhibited statistically significant drops and lasts for three to five minutes. After the infusion, the BUN and serum creatinine levels of group that received radiocontrast material were significantly higher than that of the other groups. Consequently we can emphasize that hyperosmolality and the associated hemodynamic changes are not directly responsible for contrast associated nephropathy.