Effects of somatostatin and octreotide on bacterial translocation in acute pancreatitis

Abstract

Background: The mafority of deaths in acute pancreatitis result from septic complications. Several medical methods are used in the treatment of acute pancreatitis, including somatostatin or octreotide. Aim: We aimed to investigate the possible effects of somatostatin and octreotide on bacterial translocation in an acute pancreatitis model. Material and Methods: Sixty Wistar-Albino type male rats vere randomly assigned to four groups. Group I was the sham operated group. in group II, pancreatobiliary duct ligation(PBDL) was performed. in group III, PBDL was follovedby octreotide administration (20 $mu$g/kg). Group IV, received somatostatin (5 $mu$g/kg) following PBDL. The rats vere sacrifıced 48 hours later, and blood for blood culture (1-3 mi), and tissue samples from the mesenteric lymph nodes (MLN), liver, spleen and pancreas vere taken under sterile conditions in order to investigate bacterial translocation (BT). Results: BT was observed in the MLN of only one rat (8%) in Group I. Growth was observed in 7 (58%) of the MLN cultures and in 8 (67%) samples of the liver, spleen or pancreas cultures in Group II. in Group III, 9 (75%) of the MLN and pancreas samples, and 8 (67%) of the liver and spleen samples shoved bacterial growth. All the samples of the liver, spleen and pancreas in Group IV showed growth (100%). Conclusion: in planning somatostatin and octreotide administration in the treatment of acute pancreatitis, it should be borne in mind that especially in necrotizing acute pancreatitis, somatostatin might cause increases in bacterial translocation.