Phyllodes tumor of the breast: Case series of 40 patients

Özet

Amaç: Memenin fibroepitelyal tümörlerinde Cystosarcoma phylloides nadirdir. Yüksek oranda rekürrens göstermesiyle agresiv davranışa sahiptir. Metod: Bu retrospektif çalışmada, klinik tabloyla histopatolojik bulguların ilgisini analiz ettik. Çalışmaya 40 hasta dahil edildi. Cerrahi yaklaşım tipleri, rekürrensler, histopatolojik diagnoz ve hastaların takibi çalışıldı. Histopatolojik bir çalışma yapıldı ve sonuçların klinik ve patolojik parametre bağlantıları Logistic Regression Analise ile değerlendirildi. Bulgular: Tüm hastalara ilk tedavi olarak cerrahi uygulandı. İlk çalışmada 38 vaka benign geri kalan 2 vaka malign olarak değerlendirildi. Takipte rekürrens zamanı ortalama 30.1 ay olan 9 vaka (%22.5) saptandı. Rekürren vakaların 5'i malign olarak değerlendirildi. Toplam malign vaka sayısı 7'ye (%17.5) yükseldi. İstatiksel analizlerde tümör nekrozu, stromal atipizm, stromal sellularite, mitoz sayısı ve stromaya yayılım bulguları malignite ile anlamlı olarak (p

Abstract

Purpose: Cystosarcoma phyllodes is a rare, uncommon fibroepithelial tumor of the breast. In this retrospective study, we analyzed the relation of clinical situations with histopathologic findings. Methods: Forty patients were enrolled in the study. The types of surgery, recurrences, histopathologic diagnoses and follow-ups of the patients were studied. A histopathologic examination was performed and the results were evaluated with logistic regression analysis to determine a correlation between these clinical and pathologic parameters. Results: Surgery was performed in all patients as an initial treatment. In the first examination 38 cases were evaluated as benign and the remaining 2 were malignant. Recurrent tumors were seen in 9 (22.5%) cases at follow-up with a mean recurrence time of 30.1 months. Five of the recurrent cases were evaluated as malign. The total number of malignant cases was 7 (17.5%). In statistical analyses, evidence of tumor necrosis, stromal atypism, stromal cellularity, number of mitoses and stromal overgrowth were found to be significantly correlated with malignancy (p