Leptospirozisli danalarda oksidatif stres ve bazı biyokimyasal parametreler

Özet

Bu çal ı ş ma, leptospirozisli danalarda oksidatif stres ve bazı biyokimyasal parametrelerdekide ğ i ş imleri belirlemek amacı yla yap ı lm ı ş tı r. Ara ş tı rman ı n materyalini 3-5 ayl ı k 10 adet leptospirozistan ı s ı konan dana ile ayn ı ya ş larda 10 adet sa ğ l ı kl ı danadan olu ş an toplam 20 adet danaolu ş turmu ş tur. Tüm hayvanlarda malondialdehid (MDA), plazma katalaz (CAT) veglutathiyonperoksidaz (GSH-Px), total protein, albumin, alkalen fosfataz (ALP), aspartataminotransferaz (AST), laktat dehidrogenaz (LDH), gama glutamiltransferaz (GGT), kan ürenitrojen (BUN), glikoz ve total bilirubin düzeyleri belirlenmi ş tir. Ara ş tı rma sonucunda, MDAdüzeylerinin leptospirozisli grupta kontrol grubuna göre istatistiksel olarak (P

Abstract

The aim of this study was to determine the oxidative stress and changes of some biochemicalparameters in calves with leptspirosis. In this study, 20 calves were used consisting of 10 healthycalves and 10 calves with leptospirosis. The malondialdehide (MDA), plasma catalase (CAT),glutathiyon peroxidase (GSH-Px), total protein, albumin, alkaline phosphatase (ALP), aspartatamino transferase (AST), lactate dehydrogenase (LDH), gama glutamyl transferase (GGT), bloodurea nitrogen (BUN), glucose and total bilirubin levels were determined in all calves. The MDAlevels was higher in the infected calves compared to control, but GSH-Px ve CAT levels werelower. ALP, AST, LDH, GGT, BUN, total bilirubin and total protein levels was higher in sick calvescompared to controls, but albumine and ve glucose levels was lower in the infected calves. Inconclusion, the oxidative stress was determined during leptospirosis. Furthermore, the biohemicalchanges to evidence that liver andrenal injury was determined during leptospirosis.