Dergiler / Ege Tıp Dergisi / 2021 / Cilt: 60 - Sayı: 1
Rekürren over kanseri hastalarında uygulanan tersiyer ve kuaterner sitoredüksiyon cerrahilerinin sağ kalıma etkisi ve morbiditesi
- Dergi
- Ege Tıp Dergisi
- Sayfa
- 20–31
- DOI
- —
Özet
Amaç: Rekürren over kanseri hastalarında uygulanan tersiyer ve kuaterner sitoredüktif cerrahilerin sağ kalım ve morbidite sonuçlarının incelenmesidir. Gereç ve Yöntem: Hasta kayıtları retrospektif olarak incelenmiştir. Sağ kalım oranlarının tespitinde Kaplan-Meier sağ kalım analizi ve karşılaştırmalar için log-rank testleri kullanılmıştır. Tüm analizlerde anlamlı istatistiki değer p:
Abstract
Aim: To analyze the outcomes of tertiary and quaternary cytoreduction surgeries in recurrent ovarian cancer patients. Materials and Methods: Patients’ data were obtained retrospectively from hospital database. Kaplan-Meier method has been used to analyze survival outcomes. Results: A hundred and six patients diagnosed with recurrent ovarian cancer between dates February 2007-February 2012 were included into study. Tertiary and quaternary cytoreduction surgeries have been performed in 47 and 15 patients, respectively. Mean age at diagnosis was 54.1±11.2 years. Median follow up time was 40 months (min.: 4; max.: 130 months). Overall and median survival times were 66.5±5.1 and 56 months, respectively. Overall survival of patients operated for tertiary cytoreduction was significantly longer than survival of patients who had second recurrence but not operated and given chemotherapy only (73.8±7.3 vs 52.0±5.6 months) (p:0.039). Overall survival of platin-sensitive group was longer than platin-resistant group among tertiary cytoreduction group (78.8±8.2 vs 44.4±6.4), (p:0.121). Overall survival of patients operated for fourth time and given chemotherapy only were 63.7±7.5; 62.7±8.3 months respectively (p:0.616). Intraoperative complication rate is around 15% for both tertiary and quaternary cytoreduction. Postoperative complication rate is around 20-25%. The rate of intensive care unit requirement was highest after third and fourth cytoreductive surgeries compared to first and second cytoreduction and this difference was statistically significant (p: