5-7 Yaş Arası Çocuklarda Düşük Doğum Ağırlığı ve Prematüretenin Kemik Mineral Dansitenin Üzerine Uzun Dönem Etkisi

The Long-Term Effect of Very Low Birth Weight and Prematurity On Bone Mineral Density In 5-7 Years Old Children

Özet

Giriş: Çok düşük doğum ağırlıklı bebekler, intrauterin kemik mineralizasyonun kesintiye uğraması nedeniyle prematüre osteopeni riski altındadır. Bu çalışmada çok düşük doğum ağırlıklı ve preterm doğan 5-7 yaş arası çocuklarda kemik mineral yoğunluğunun DXA ile değerlendirilmesi amaçlandı. Yöntemler: Bu çalışma, Şubat 2011 ve Eylül 2012 arasında prospektif olarak gerçekleştirildi. Bin beş yüz gramın altında doğan 5-7 yaş arası 75 çocuk dahil edildi. Bulgular: Çalışma grubunun kemik yoğunluğu ölçümleri (42 kadın %56) DXA referans değerlerine göre düşük bulundu (p

Abstract

Objective: Very low birth weight (VLBW) infants are at increased risk of osteopenia of prematurity due to interruptionof intrauterine bone mineralization. In this study aimed to evaluate the bone mineral density (BMD) by evaluating DXAin children aged 5-7 years with VLBW and preterm birth.Methods: This study was conducted prospectively between February 2011 and September 2012. Seventy-five childrenaged 5-7 years, who were born under 1.500 grams were included.Results: Bone density measurements of the study group (42 female 56%) were found to be low compared to the DXAreference values (p < 0.001). According to the L1-L4 Z score, bone density was found to be low in 21.33% (n: 16) of thecases. Total femur Z score (p = 0.018), femur neck BMD (p = 0.001), total femur BMD (p = 0.012) values were significantlylower in females than males. Whole body BMD values (p = 0.021) were significantly lower in patients receiving postnatalsystemic steroids than in the non-receiving group. Femur neck BMD values of the patients who received only breast milkin the first six months were found to be statistically significantly higher than those who received only formula in the firstsix months (p = 0.034).A significant correlation was found between the current height, weight, BMI increase and BMDmeasurement.Conclusion: In this study, it was shown that bone diseases in VLBW and preterm infants affect bone mineralization inlong term. We determined the effects of drugs and nutrition used in treatments and current anthropometricmeasurements on bone health of preterm and VLBW.