Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi

Evaluation of Mental and Behavioral Disorders in Patients Who Have Applied to the Disability Board of a District State Hospital in Diyarbakir

Özet

Objective: Numerous studies investigating Vitamin D receptor (VDR) polymorphisms in different populations have been present in current literature. For this reason, we designed a study to investigate the role of three known common VDR genetic polymorphisms (Apa-I/rs7975232, Bsm-I/ rs1544410 and Taq-I/rs731236) in Turkish individuals affected by Obstructive sleep apnea syndrome (OSAS). Methods: The study was carried out on a total of 175 consecutive subjects, including 80 OSAS patients and 95 healthy participants. Single Nucleotide Polymorphism (SNP) Detection was performed with the iPLEX® Assay and the MassARRAY® System for detection of Apa-I (rs7975232), Bsm-I (rs1544410), and Taq-I (rs731236) polymorphisms. Results: Fifty-seven C alleles (71.3%) and 59 T alleles (73.8%) were detected in the group of 80 OSAS patients in terms of rs1544410 polymorphism. When the patient and control groups were evaluated statistically at allelic level, it was observed that the T allele increased the risk of disease and this increase was statistically significant (Odds Ratio (OR) = 1.549 [Confidence Interval (CI): 1.012-2.371], (p=0.043). However, there were no significant differences between other VDR polymorphisms (rs7975232 and rs731236) and OSAS clinical data (p=0.6 and p=0.9, respectively). Discussion: As a conclusion, no statistically significant relationship was found between all three VDR polymorphisms and OSAS patients' clinical features. Further studies should be performed by creating a large sampling group. Finally, population studies should be given importance considering the variability of polymorphism according to ethnic origin.

Abstract

Objective: Although disability is a major problem in our country, there are few studies on this subject. The aim of this study was to determine the demographic characteristics and the prevalence of psychiatric diagnoses of people with a disability board report from a district state hospital serving rural areas. Method: The files of 3842 people who applied to a district state hospital’s disability board between September 2016 and February 2019 were retrospectively investigated. Demographic information, diagnoses and disability rates of 576 individuals who were given a psychiatric disability rate were examined. Results: Of the individuals who had been given a psychiatric diagnosis and disability rate, 312 were male (54.2%), 264 of them were female (45.8%), and the mean age was 42.6±17.4. The mean total disability rate was 62.7±20.9% and the rate of disability related to psychiatry was 42.5±22.5%. The number of people who were decided by the disability board to be severely disabled since they could not perform their daily activities without the help of others was 96 (0.2%). The first five psychiatric diagnoses with the highest rate of disability were schizophrenia- treatment resistant (17.4%), generalized anxiety disorder- partial response (17.4%), mild mental retardation (IQ:50-69) (12.5%), borderline mental capacity (IQ: 70-80) (11.7%) and dysthymia- partial response (8.7%). Conclusions: Our study revealed that the most common causes of psychiatric disability are schizophrenia and generalized anxiety disorder. This study may be useful in revealing the situation of mentally and behaviorally disabled people in our country and may also serve as a guide in making arrangements regarding these people.