Süt çocuklarında anne kaynaklı kızamık antikorlarının varlığı

Özet

Bu prospektif çalışma çocuklarda anne kaynaklı kızamık antikorlarının kaybolma zamanını belirlemek amacıyla yapıldı. Araştırmaya İstanbul Tıp Fakültesi Doğum Kliniği'nde zamanında doğan, sağlıklı 30 yenidoğan ve anneleri alındı. Anneden ve göbek kordonundan doğumdan hemen sonra, bebeklerden dördüncü, altıncı ve dokuzuncu aylarda kan alındı. Tüm örneklerde ELISA ile kızamık IgG antikorları çalışıldı. Kızamık antikoru pozitiflik oranları anne ve kordon kanında %100 iken, bu oran dördüncü ayda %90, altıncı ayda %53 ve dokuzuncu ayda %6.6 bulundu. Tüm kan örnekleri karşılaştırıldığında aralarında istatistiksel olarak anlamlı fark olduğu belirlendi (p

Abstract

Since measles is still seen in Turkey, infants receive the measles vaccine at nine months of age. However, the age of immunization is in debate due to the probable interference of persistence of passive measles antibody titers in infants up to the age of nine months. The study included 30 healthy mother-infant pairs at the maternity clinic of the İstanbul Medical Faculty Hospital. All mothers had blood drawn at the time of delivery. Cord blood from their offspring was obtained, and blood was collected from these infants again at four, six and nine months of age. Measles IgG antibody titer was determined by ELISA method. The proportion of antibody positive mothers was 100 percent. The proportion of antibody positive babies was 100 percent at birth, 90 percent at four months, 53 percent at six months and 6.6 percent at nine months. Only three mothers had the measles vaccination. The persistence of passive measles antibody was negligible in infants at nine months of age. This negligibility value is very near to the value recommended by WHO for the achievement of optimal immunization by the Schwarz strain. Our results showed that the measles vaccination should be continued at nine months of age for the prevention of measles among seronegative infants.