Evaluation of Platelet Large Cell Ratio (PLCR) Results in Patients with Preeclampsia and HELLP

Abstract

BACKGROUND/AIMS: Preeclampsia is a multi-systemic syndrome that often occurs after the 20th week of pregnancy. It is one of the main causes of maternal morbidity and mortality in the obstetric population. There is still a debate about whether hemolysis, elevated liver enzyme levels, and low platelet levels (HELLP) is a form of severe preeclampsia or a separate disease. We aimed to find a relationship between platelet large cell ratio (PLCR) and preeclampsia in our study, and try to assess whether this parameter could be used as marker for early diagnosis. MATERIALS AND METHODS: This retrospective cohort study included 86 preeclampsia and 50 normotensive patients who were admitted to İstanbul Training and Research Hospital between January 2018 and December 2019. Complete blood count values from preeclampsia and normotensive pregnancies were measured using an automated hematological analyzer (XN 3000, Sysmex Corp., Kobe, Japan) at their first entry to the emergency service department. The PLCR value was calculated using data from full blood count analysis. Hemogram and biochemistry results were compared in the preeclampsia and control groups from the patient records. RESULTS: No statistically significant difference was found among the body mass index (BMI), PLCR, hemoglobin (Hg), hematocrit (Hct) and platelet values of the preeclampsia and control group pregnant women. The PLCR values showed a statistically significant positive correlation with alanine transaminase, aspartate aminotransferase, urea, and lactate dehydrogenase values (p