ANALGESIC EFFECT OF PRE-EMPTIVE ORAL NSAIDS ON POST- ENDODONTIC PAIN LEVELS IN SINGLE VISIT ENDODONTICS -A SYSTEMATIC REVIEW

Abstract

Pre-emptive analgesia is an anti-nociceptive treatment that reduces postoperative pain by preventing altered afferent input. As most of the patients present with pain preoperatively have higher levels of released local inflammatory mediators. Thus, pretreatment analgesia decreases the establishment of central sensitization, a mechanism by which spinal neurons increase their response to the peripheral nociceptive impulse. This systematic review aims to compare and evaluate the postoperative pain levels and analgesic intake on NSAIDs' preoperative oral administration in single visit root canal treatment. According to PRISMA guidelines, the present review was done and was registered in the PROSPERO (Centre for Reviews and Dissemination University of York.). Registration number-CRD42020195775. The research question was formulated based on the PICO strategy. A comprehensive electronic literature search was conducted across PubMed/Medline, Scopus and Cochrane Database independently by two reviewers. Articles published from January 1990 to May 2019 that focused on pre- emptive strategies in single visit root canal treatment were included in the present review. Based on specified inclusion and exclusion criteria's, the selected articles were subjected to quality assessment, and the risk of bias was evaluated. A total of 6 articles were included, out of which three were hand searched. The overall risk of bias of included studies was moderate, and the study limitations were high. Among the studies included, Ibuprofen was considered as the best drug of choice in single visit endodontics.