Comparison Clinical Effects of Concentrated Growth Factor and Platelet-Rich Fibrin In the Treatment of Localized Gingival Recessions: A Split-Mouth Randomized Clinical Trial

Abstract

Background and Aims: The purpose of this study was to evaluate the clinical efficacy of concentrated-growth-factor (CGF) in combination with coronally-advanced-flap (CAF) compared with platelet-rich-fibrin (PRF)+CAF for the treatment of localized gingival-recessions (GRs) Methods: 18 subjects with localized GRs were randomly treated according to a split-mouth design in the maxilla using CGF+CAF (test site), or PRF+CAF (control site). Clinical outcomes were assessed at baseline and at 6 months after surgery for the following terms: complete-root-coverage (CRC), mean root-coverage (MRC) clinical-attachment-level (CAL), recession depth (RD), keratinized-gingiva-width (KGW), gingival-thickness (GT), recession-width (RW). Results: A statistically significant difference was observed in CAL, RD, KGW, GT and RW at 6 months compared to baseline values in both therapy sites. MRC was 85.18% and 82.40 %, CRC was 61.11% (11/18) and 50.00% (9/18) for the CGF site and PRF site, respectively at 6th month. No statistically significant difference was observed in these parameters between the two sites at 6 months. Conclusions: The use of CGF and PRF membranes together with CAF may increase the success of GR therapy. However, the use of CGF+CAF was not superior to PRF+CAF in providing additional benefits in clinical parameters.