Newly Axially Silicon (IV) Phthalocyanine Photosensitizer: Design, Synthesis and Photo-chemical Properties

Abstract

Phthalocyanines as used a photosensitizer in photodynamic therapy, , phthalocyanines exhibit their longwavelength absorption and the ability to produce high singlet oxygen for tumor destruction with 650 to 900nm fluorescence. In this study, new axially substituted silicon (IV) phthalocyanine (PS-4) was synthesizedto determine photo-chemical properties using 2-methoxyethanol as an axial ligand to increase singletoxygen quantum yield. Structural characterization of this new axially substituted silicon (IV)phthalocyanine were performed by IR, mass, 1H NMR and UV-Vis spectroscopic techniques. As axiallysubstituted silicon (IV) phthalocyanine (PS-4) is thought to be a promising PDT agent, photo-chemicalproperties for cancer treatment with PDT have been investigated.