Dergiler / Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :A-Uygulamalı Bilimler ve Mühendislik / 2018 / Cilt: 19 - Sayı: 1

NEW THIOPHENE BEARING DIMETHYL-5-HYDROXY ISOPHTALATE ESTERS AND THEIR ANTIMICROBIAL ACTIVITIES

NEW THIOPHENE BEARING DIMETHYL-5-HYDROXY ISOPHTALATE ESTERS AND THEIR ANTIMICROBIAL ACTIVITIES

Hakan ÜNVER, Zerrin CANTÜRK

Sayfa
43–49
DOI
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Abstract

Thiophene belongs to a class of heterocyclic compounds. In this study, three new dimethyl-5-hydroxy isophtalate derivedthiophene esters were successfully synthesized and characterized by FT-IR, Elementel Analysis, 1H-NMR, 13C-NMR and HRMasstechniques. Synthesized compounds antimicrobial effects were tested on Staphylococcus aureus (ATCC 25923);Enterococcus faecalis (ATCC 29212); Enterococcus faecalis (ATCC 51922); Klebsiella pneumoniae (ATCC 700603);Pseudomonas aeruginosa (ATCC 27853); Escherichia coli (ATCC 35218); Escherichia coli (ATCC 25922) and Candidaalbicans (ATCC 90028); Candida glabrata (ATCC 90030); Candida krusei (ATCC 6258); Candida parapsilosis (ATCC22019). Compound C1 showed the highest antimicrobial activity, possessing the same potential as chloramphenicol against, P.aeruginosa ATCC 27853. According to MTT assays, this compound (C1) was identified as non-toxic.