Synthesis of new heterocycles via methylenebis(2-(2-methoxyphenyl)thiazolidin-4-one) as potential anticancer agents

Özet

NaOAc catalyzed condensation of bis(2-(2-methoxyphenyl)thiazolidin-4-one) with pmethoxybenzaldehyde in AcOH gave the corresponding chalcones. Cyclization of the synthesized chalcones with NH2OH by refluxing in AcOH afforded the related isoxazoles fused with thiazoles. All the synthesized isoxazoles were evaluated against different tumor cell lines. Almost all compounds showed activity against prostate cancer cell lines.