Comparison of Visual and Anatomical Outcomes of Half Fluence - Full Dose and Half Dose - Full Fluence Photodynamic Therapy in Eyes with Chronic Central Serous Chorioretinopathy

Özet

Purpose: To compare half fluence-full dose and half dose- full fluence photodynamic therapy (PDT) regarding visual acuity and anatomic changes in chronic central serous chorioretinopathy (CSCR). Materials and Methods: We retrospectively reviewed 60 patients with chronic CSCR patients who underwent half fluence- full dose (group 1, 30 patients) or half dose- full fluence (group 2, 30 patients). The best corrected visual acuity (BCVA), central macular thickness (CMT), subfoveal choroidal thickness (SFCT), serous retinal detachment (SRD) and retina pigment epithelial detachment (PED) were compa red between the groups at baseline, on months 1, 3, 6 and 12 during follow-up. Results: The mean follow-up duration was 12 months in both groups. The mean number of repeated PDTs following first PDT was 0.48 ± 0.20 (range, 0-2) in the group 1 and 1.09 ± 0.80 (range, 0-3) in the group 2 during 12-months follow-up (p = 0.031). In Group 1 , BCVA was increased from 0.69 ± 0.28 logMAR (logarithm of the Minimum Angle of Resolution) at baseline to 0.20 ± 0.18 logMAR on month 12 (p 0.05). In the study, number of PDTs were increased by decreasing doses administered in PDT (r = -0.339, p =0.008). In both groups, no PDT-related complication was observed. Conclusion: Both half fluence-full dose and half dose-full fluence PDT were effective in the treatment of chronic CSCR. No signi ficant difference was observed in visual or anatomical outcomes between groups. Although no systemic complications developed depending on the PDT dose, the number of relapses increased by reducing amount of doses. amount decreased. Based on these results, we observed t hat the number of PDT relapses can be related to the dose amount.