Prevalence of Non-Alcoholic Fatty Liver Disease in Patients with Parkinson Disease

Özet

Objectives: Non-alcoholic fatty liver disease (NAFLD) has presented as the most common cause of chronicliver disease in the Western world. Parkinson disease (PD) is these most common non-demyelinizan neurologic disase and its incidence is steadily increasing in the world. Our study aims to analyze the prevalence ofultrasonography-proven NAFLD among the PD patients.Methods: A retrospective chart review was performed to identify PD patients who had at least two visits inthe Liver Clinic from January 2017 to May 2018. Thus, 124 consecutive patients with PD was longitudinallyscreened for NAFLD which were diagnosed according to ultrasonographic criteria. Control subjects were selected from age-matched eldely subjects. Demographic and laboratory data, concurrent statin use and resultsof hepatobiliary ultrasonography were collected.Results: Non-alcoholic fatty liver disease prevalence was significantly lower in the PD group than in the agematched control group (21.0% vs. 36.9%, p=0.014). In multiple logistic regression analyses using baseline factors, statin use, elevated HbA1c, baseline fasting glucose below than 100 mg/dL, and elevated ALT levels wereindependently associated with NAFLD (p=0.040, p<0.001, p=0.030, and p<0.001, respectively).Conclusion: While additional studies in large populations are needed to investigate the correlation betweenPD and NAFLD, further exploration of PD-related metabolic liver disease clinically appears warranted.