Evaluation of Levels of Serum IgE and Rectal Mucosal Eosinophilia in Irritable Bowel Syndrome

Özet

Objectives: Irritable bowel syndrome (IBS) and food allergic reactions are common in the community and cancause symptoms similar to each other. In this study, it is aimed to evaluate serum immunglobulin E (IgE) andrectum mucosal eosinophilia levels in IBS.Methods: Record of patients who applied between April 2013 and April 2014 were retrospectively screenedand patients who were 18–70 years old and previously performed rectal biopsy by colonoscopy and diagnosed with IBS according to Rome III criteria were included in the study. All patients were grouped as diarrhealdominant IBS (IBS-D), constipation dominant IBS (IBS-C), mix type IBS (IBS-M) and unclassified IBS (IBS-U) according to their symptoms. In addition, serum IgE levels and rectal mucosal eosinophilia levels were evaluatedfrom all patients' records.Results: 39 (56.52%) of total 69 patients with IBS were in the IBS-C group, 19 (27.54%) of them were in theIBS-D, 9 (13.04%) of them were in the IBS-M and 2 (2.90%) of them were in the IBS-U. There were not anysignificant differences between IBS subgroups in terms of presence of allergic disease and presence of foodallergy (p=0.519 and p=0.849, respectively). The median level of rectal eosinophilia in IBS subgroups was foundto be 2.00 (0.00 to 88.00) in IBS-C subgroup, 5.00 (0.00–100.00) in IBS-D subgroup and 2.00 (0.00 to 11.00) inIBS-M subgroup. In addition, IgE levels were found high in 7 (19.45%) of IBS-C subgroup, 7 (36.84%) of IBS-Dsubgroup and 3 (33.33%) of IBS-M group (p=0.348).Conclusion: In this study, relation between serum IgE and rectal eosinophilia levels with IBS subgroups couldnot not found.