Evaluation of Comorbidities in Patients with Autoimmune Bullous Diseases: A Retrospective Study

Özet

Objectives: The purpose of the present study was to define the accompanying diseases of patients with autoimmune bullousdiseases (ABDs).Methods: One hundred forty-two patients with ABD who were followed up in the dermatology and venereology inpatient clinicof Şişli Hamidiye Etfal Training and Research Hospital between January 1999 and December 2015 were enrolled in the study. Age,gender, and accompanying diseases of the participants were recorded and compared with the healthy subjects.Results: Eighty patients with pemphigus, 62 patients with pemphigoid, and 217 healthy subjects were included in the study. Thepemphigoid group had a statistically significant higher prevalence of hypertension, diabetes mellitus, coronary artery diseases,cataract, malignancy, dementia, Alzheimer’s disease, Parkinson’s disease, and cerebrovascular events relative to the pemphigusand control groups (p<0.01, p<0.01, p=0.001, p<0.01, p=0.02, p=0.008, p=0.001, p=0.001, and p<0.01, respectively). The prevalenceof asthma, benign prostatic hyperplasia, and cataract was higher in the pemphigus group than in the controls (p=0.02,p=0.04, and p=0.02, respectively).Conclusion: To the best of our knowledge, this is the first study comparing accompanying diseases between controls and patientswith pemphigus and pemphigoid. It is disputable whether the diseases mentioned occur due to some common pathophysiologicalpathways or coexist just coincidentally. We believe that it is important to evaluate accompanying diseases in patients with ABD.