Development of Multiple-Lesion Basal Cell Carcinoma of the Skin: A Comprehensive Review

Özet

An interesting clinical feature of basal cell carcinoma (BCC) of the skin is a marked variation in tumor number, sites, and accrual.Some individuals develop only a single BCC lesion with no impact on health status, while a significant proportion is affectedrepeatedly with new primary tumors at various body sites. Approximately 29% of patients with a first BCC will develop at least 1more lesion during their lifetime. The candidate predictors for multiple BCC development include younger age and a superficialBCC subtype at the time of the first diagnosis, red hair phenotype, initial or frequent tumor location on the trunk or on the upperlimbs, and male gender. The pathogenesis of multiple BCC development does not seem to be related to greater UVR exposure.Individual genetic susceptibility may have a greater impact than extrinsic factors. In clinical practice, it is meaningful to estimatethe probability of new BCC development in patients who have an initial lesion. A reliable prediction model for individualized riskstratification remains a subject of continued research; however, a focus on the risk factor profile is beneficial for clinical screeningand may help clinicians to determine the individuals who should be followed up more closely.