The Impact of Red Cell Distribution Width on the Development of Contrast-Induced Nephropathy in Patients with Stable Coronary Artery Disease who Underwent Coronary Angiography

Özet

Objectives: Contrast-induced nephropathy (CIN) accounts for 10% of all causes of hospital-acquired renal failure. The pathophysiologicalcellular mechanism of the CIN development remains unclear and seems to be multifactorial. Herein, we aimed to determinethe role of red cell distribution width (RDW) in the development of CIN after elective percutaneous intervention in patientswith stable coronary artery disease, which in our opinion has not been researched enough.Methods: Between October 2009 and October 2011, a total of 211 patients with stable coronary artery disease who had undergonea coronary intervention procedure were evaluated prospectively. The patients were classified according to the developmentof CIN, and both groups were compared statistically according to clinical, laboratory, and demographic features, including theserum RDW level.Results: In 18.8% of the patients, CIN was observed. The mean age was 64±10.5, and 59% of the study group was male. An advancedage, male gender, hypertension, the serum total protein level, high density lipoprotein, and albumin levels were correlatedwith the development of CIN. The mean RDW level was 13.7±1.4%, and the mean creatinine level was 1.0±0.2 mg/dL. There wasnot any correlation between RDW and the presence of CIN (CIN[−]=13.8±1.5, CIN[+]=13.6±1.0, p>0.05), and also a multivariateregression analysis proved this non-correlation (OR : 0.92, 95% confidence interval [CI]=0.62–1.34; p: 0.67 ). There was only a correlationbetween hypertension and male gender with CIN that was proved with a multivariate regression analysis (OR=5.74, 95% CI:1.96–16.79, p<0.01 vs OR=5.34, 95% CI=1.22–23.3, p: 0.02, respectively).Conclusion: Our outcomes indicate that the RDW has a limited use as a CIN predictor in patients with stable coronary artery disease.