Comparison of the Oral Steroids, Macrolides and Combination Therapy in Nasal Polyposis Patients

Özet

Objectives: In this study, our aim was to compare oral steroid therapy with macrolide therapy and with oral steroid + macrolide(combine) therapy in patients with nasal polyposis (NP).Methods: All patients were treated with nasal steroid therapy for eight weeks and divided randomly into three groups as follows:Oral steroid group, oral macrolide group and combine group. All patients underwent endoscopic staging, radiological grading,odour testing and completed the sino-nasal outcome test-22 (SNOT-22) questionnaire before and after treatment.Results: Significant improvement was observed in all parameters after treatment in all three groups. All parameters were significantlybetter in the combined group than in the macrolide group. Comparison of the oral steroid group and macrolide grouprevealed significantly better radiological grading and odour test changes for the oral steroid group, but no statistically significantdifferences existed according to endoscopic staging and SNOT-22. The post-treatment SNOT-22 score was significantly better inthe combined group than in the steroid group. A comparison of the combined and steroid groups showed better results for thecombined group for all parameters, but the differences were not significant.Conclusion: All treatment protocols were effective and the successful use of macrolide indicates its potential as an alternative inpatients with contraindications to oral steroid treatment. The combined treatment may demonstrate significantly better resultsthan steroid treatment alone if larger studies with more patients are performed.