Establishment of a large animal model for research on transbronchial arterial intervention for lung cancer

Özet

PURPOSEWe aimed to evaluate whether bronchial artery can supply a percutaneously inoculated caninetransmissible venereal tumor (CTVT) in a lung tumor model.METHODSFresh CTVT tissue blocks were percutaneously inoculated into unilateral or bilateral lungs of siximmunosuppressed dogs at the mid zone of the middle or lower lobe. Tumor growth was monitored by computed tomography (CT). Ten weeks after inoculation, pulmonary arterial digitalsubtraction angiography (DSA), bronchial arterial DSA, transpulmonary arterial contrast-enhanced multislice CT, transbronchial arterial contrast-enhanced multislice CT (BA-MSCT), andtranspulmonary arterial lipiodol multislice CT were performed.RESULTSTumor growth was seen in all 10 inoculated sites, with a maximum diameter of 2.734±0.138 cmat 10th week. Bronchial arterial blood supply was evident in 9 nodules on DSA, and was equivocal in one which was later demonstrated on BA-MSCT. No obvious pulmonary arterial bloodsupply was observed in any of the nodules. Lipiodol deposition was displayed in two of thesmall distant metastases, which indicated that pulmonary artery was involved in the supply ofthe metastases.CONCLUSIONOur results demonstrated bronchial arterial blood supply in this new lung cancer model. Thismodel may be used in further research on transbronchial arterial intervention for lung cancer