Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study

Özet

Aim: It is known that muscle mass decreases with age. Sometimes it may be possible to adversely affect this reduction. It was aimedto investigate the contribution of claudin-5 and E-cadherin to this process.Methods: Samples were taken from the psoas muscle of 55 cases autopsied for different reasons between 2018-2019. Age, gender,weight, height, chronic disease, and addiction were recorded. Histopathological degeneration parameters were evaluated. In addition,samples were prepared for immunohistochemical study. Evaluation for E-cadherin and claudin-5; no staining, weak staining, moderatestaining and severe staining. Fibrosis was evaluated with Masson trichrome.Results: There was a very strong and statistically significant inverse relationship between acidophilic sarcoplasma and staining withclaudin-5 (p 0.05).Conclusion: Claudin-5 can be a target protein that can be used in the detection and prophylaxis of degeneration and atrophy instriated muscles.