Risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis: Evidence from 810 cases Risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis: Evidence from 810 cases

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Introduction: The risk and causes of post ERCP pancreatitis and associated risk factors are summarized,and potential prophylactic measures with strong evidence for effective prevention of post ERCP pancreatitisare discussed.Materials and Methods: Prospectively collected patient data were reviewed retrospectively for a total of 810ERCPs undertaken in our hospital between June 2015 and September 2018. All ERCP procedures were performed by a single surgeon. Risk factors for post-ERCP pancreatitis were investigated, which included endoscopist experience, ERCP team and ERCP room equipment. We focused on factors related to endoscopistexperience, ERCP team and ERCP room equipment.Results: A total of 810 patients, including 439 females and 371 males, were enrolled in this study. Amylaselevels and pancreatitis were evaluated 24 hours after ERCP. Post ERCP pancreatitis developed in a total of46 (5.5%) patients out of 810 patients undergoing ERCP. Also, the incidence of post ERCP pancreatitis was2-fold higher in the first 400 patients versus in the last 400 patients. This higher post ERCP pancreatitis incidence found among the first 400 patients of our series can be explained by the relative lack of experienceand expertise of the endoscopist and the ERCP team.Conclusion: The risk of post-ERCP pancreatitis is mBahtiyar Muhammedoğluultifactorial and the effects of some of the risk factorsmay be minimized or completely eliminated. The findings suggest that endoscopist and his/her experiencehave a major role in avoiding or minimizing the negative effects of these factors.