Dergiler / Records of Natural Products / 2020 / Cilt: 14 - Sayı: 5

Scoparic acid E: A New Labdane Diterpenoid on Attenuating Palmitate Induced Viability in MIN6 Cells from Scoparia dulcis

Yiying LI,Yong ZHANG,Caiyun ZHANG,Lizhen CHEN,Na WEI,Lu ZHANG,Lin DONG,Xiaopo ZHANG

Sayfa
383–386
DOI
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Özet

A new labdane diterpenoid, named Scoparic acid E (1), was obtained from the medicinal plant ofScoparia dulcis L. The structure of Scoparic acid E (1) was elucidated and characterized through detailedphysical analyses of its NMR spectroscopic data and HRMS. Scoparic acid E (1) was tested for its effect onattenuating palmitate-induced viability at 25 and 50 μM. The results showed that compound 1 significantlyattenuated palmitate-induced viability in MIN6 cells.