Dergiler / Records of Natural Products / 2020 / Cilt: 14 - Sayı: 5

Evaluation of a New Labdane Diterpenoid from Jatropha podagrica

Dongbo ZHANG,Jingao YU,Zhen ZHANG,Yanni LIANG,Zhishu TANG,Zheng WANG

Sayfa
355–360
DOI
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Özet

Jatrodagricaine A (1), a new labdane-type diterpenoid, together with three known derivatives (2−4)were isolated from the leaves of Jatropha podagrica. Their structures were elucidated by extensive spectroscopicmethods. The absolute configuration of 1 was established by its biosynthetic pathway and comparison to knowncompound. All compounds were investigated for their anti-inflammatory and thioredoxin reductase (TrxR)inhibitory activities. Compound 1 showed potential inhibition in terms of nitric oxide (NO) production inlipopolysaccharide (LPS)-induced RAW264.7 macrophages with IC50 value of 40.6 ± 2.2 μM.