Efficacy of Gynostemma pentaphyllum Extract in Anti-obesity Therapy

Yoon Hee KİM,So Mi KİM,Jae Kyoung LEE,Sung Kwan JO,Hyung Joong KİM,Kyu Min CHA,Cho Young LİM,Joo Myung MOON,Tae Young KİM,Eun Ji KİM

Özet

In the present study, we investigated a saponin-enriched fraction from Gynostemma pentaphyllumextract (GPE) and isolated gypenoside L (GL), gypenoside LI (GLI), and ginsenoside Rg3 (Rg3). To explore the anti-obesity activities of these compounds, we investigated the effects of GL, GLI, and Rg3 on glucose uptake and activation of AMPK in L6 skeletal muscle cells. GPE, GL, GLI, and Rg3 markedly increased glucose uptakeactivity and GLUT4 gene expression in L6 myotubes. The enhanced glucose uptake was mediated by the activation of the AMPK-ACC signaling pathway. In addition, we observed that GPE, GL, GLI, and Rg3 increased the expression of SIRT1 and PPARγ coacvtivator-1α (PGC-1α). Our results suggest the potential use of Gynostemma pentaphyllum in developing a therapeutic agent to reduce body weight and prevent diet-related diseases via glucose uptake and AMPK activation.