Dergiler / Records of Natural Products / 2021 / Cilt: 15 - Sayı: 6

Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034

Semiha Çetinel AKSOY,Melis KÜÇÜKSOLAK,Ataç UZEL,Erdal BEDİR

Sayfa
602–607
DOI
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Özet

7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D- (1H and 13C NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.