Assessment of Optic Nerve Head Parameters using Optical Coherence Tomography Angiography in Behçet Uveitis Patients with Healthy Controls

Özet

Purpose: To compare the optical coherence tomography angiography (OCTA) fi ndings of Behçet uveitis (BU) patients with healthy controlsand to evaluate their correlation with the best corrected visual acuity (BCVA).Methods: We conducted a thorough ophthalmic examination and OCTA on 20 BU patients and 26 control subjects. Optic nerve head (ONH)fl ow and non-fl ow areas, capillary vessel density (CVD) at the optic disc, superfi cial capillary plexus (SCP) fl ow and non-fl ow areas (FAZ),outer retina and choriocapillaris (CC) fl ow areas, and SCP thickness at the parafoveal region were measured using OCTA.Results: We found signifi cantly lower ONH fl ow area (1.57±0.17 vs. 1.68±0.08 mm2) and CVD at the optic disc (OD)-centered 4.5x4.5 mm2area (53.99±4.94 vs. 58.13±1.77%) (p 0.05). There was a negative correlation between BCVA (logMAR) and the ONH fl ow area (r= -0.363,p=0.049), SCP fl ow area (r= -0.703, p<0.001), parafoveal SCP thickness (r= -0.348, p=0.035) and CVD in the OD-centered area (r= -0.644,p=0.002) in BU patients.Conclusion: While there were no micro-vascular changes at the parafoveal region. The CC, ONH-related parameters such as decreased ONHfl ow area and CVD at the optic disc and increased ONH non-fl ow area were observed regardless of disease duration and visual acuity in BUpatients.