Histological evaluation of implantation deficit in experimentally induced e ndometriosis model of rats

Abstract

Background: Experimental animal models are impor- tant in understanding human endometriotic disease. Aims: This study aims to describe factors influencing the implantation deficit in experimental endometriosis. Material and Method: Decidua reaction were detected in surgical endometriosis induction group (n=20), sham operated (n=10) and non-operated control (n=10) groups and studied with routine light microscopic, electron microscopic and immunohistochemical techniques as well as histologic, morphometric and biochemical analysis. Results: Decidualisation and pinopode expression of eutopic endometrium in surgically induced endometriosis relatively decreased and adequate endometrial morpho- logy may not always display normal endometrial receptivity. Although mitotic figures were described, study groups revealed statistically significant thickness differences in morphometry. Conclusions: Uterine receptivity defects are regulated differently while other alternative mechanisms effecting endometrial receptivity sustained. In addition, unsignifi- cant differences of immunohistochemical expressions are non-descriptive due to the antibodies used for uterine receptivity in experimental endometriosis. Yet, morpho- metry may pioneer novel ultrasonographic modules in future.