Researching Predictive Value of White Blood Cell Rates for Diagnosis of Prostate Cancer in the Patients Undergoing Prostate Biopsy: A Pilot Study

Özet

Objective: The aim of this study was to assess the usefulness of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), plateletto- lymphocyte ratio (PLR) and neutrophil-to-monocyte (NMR) as biomarkers in men who had a prostate-specific antigen (PSA) level of 4 to 10 ng/mL and who subsequently underwent prostate biopsy. Materials and Methods: We retrospectively analyzed the records of 546 patients who underwent multicore (≥12) TRUS-guided biopsy at our institution between April 2010 and November 2017. Age, PSA level, f/t PSA, NLR, PLR, LMR, NMR, Gleason score in patients with prostate cancer (PCa) and biopsy results were collected. Histological results were categorized into three groups as benign prostatic hyperplasia, prostatitis and PCa. Results: The median age of patients was 64 years. The mean total PSA level and f/t PSA ratio were 6.52±1.76 and 0.2±0.09, respectively. The mean NLR, LMR, PLR and NMR were 2.46±1.46, 3.94±2.07, 120.69±60.73 and 8.52±7.97, respectively. The f/t PSA ratio in the PCa group was significantly lower compared to the other two groups (p<0.001). There was no statistically difference in NLR, LMR, PLR and NMR values (p=0.293, p=0.066, p=0.189 and p=0.334, respectively). Multivariate logistic regression analysis showed that age, PLR and f/t PSA were more likely to detect PCa. (p<0.001, p=0.018 and p<0.001, respectively) Conclusion: Several studies have been published with controversial results trying to specify the predictive value of the ratios of white blood cells in diagnosis of PCa. In this study, univariate and multivariate analyses showed that PLR value would be promising for future studies. Prospective studies are needed to find biomarkers for PCa detection.