Relationship Between AMACR Staining Density of Radical Prostatectomy Specimen and Biochemical Recurrence in Patients with Pathological Stage T2a-b

Özet

Objective: This study aimed to evaluate the relationship between Alpha-methylacyl-CoA racemase (AMACR) staining intensity of pathologic specimens and Prostate Spesific Antigen (PSA) recurrence of patients with an organ-limited disease who underwent radical prostatectomy for localized prostate cancer. Materials and Methods: The data of 46 patients who underwent radical retropubic prostatectomy and who had prostate-limited disease without capsule invasion in the pathological evaluation were included in the study. AMACR expression was assessed by immunohistochemical staining. Expression levels were classified as negative (score=0), weak (score=1), moderate (score=2) and strong (score=3) staining. Patients with a PSA value of ≥0.2 ng/mL at postoperative follow-up were considered to have a biochemical recurrence. Patients were divided into two groups, according to biochemical recurrence. Groups were compared in terms of AMACR staining intensities of radical prostatectomy specimens. Results: Twenty-one patients developed PSA recurrence in a mean follow-up period of 32±8 months. The remaining 25 patients were recurrence-free. The mean recurrence time was 24±5 months. According to AMACR staining scores, the biochemical recurrence rates of the patients were 33.3%, 40.7%, and 61.5% for score 1, score 2, and score 3, respectively. Although higher rates of PSA recurrence were observed in patients with more intense AMACR staining, the difference between rates was not statistically significant (p=0.38). Conclusion: PSA recurrence rate increases with increasing AMAC-CR staining intensity. Further studies are needed to obtain statistically significant results.