Effect of Primary Testicular Tumor Localization on Prognosis and Survival of Non-seminomatous Testis Cancer Patients

Özet

Objective: Unlike left testicular vein, right testicular vein drains into inferior vena cava. Consequently, the systemic spread of testicular cancers in each side is expected to differ based on the vascular structures of the right and left testis. In this study, we investigated the effect of tumour localization on survival of nonseminomatous testicular cancer patients. Materials and Methods: We included three hundred and twenty-one (321) non seminomatous testicular cancer patients who were followed-up at Gülhane Training and Research Hospital between January 1981 and December 2015. Results: The primary tumour found in the left testis in 152 (47.2%) patients, while 170 (52.8%) patients had the primary tumour in the right testis. The lungs (n=62, 42.5%) was the most common site of metastasis. During follow-up and primary treatment, 74 (23.1%) patients had recurrence, which was common in retroperitoneal lymph nodes (10.3%) and lung (5%). Median follow-up period was 88.3 (range: 1-386) months, while median survival was 337 months in all cases. Median 10 year survival rate was 74.1%, while median 20 year survival rate was 70.7%. We found that survival of patients with the primary tumour was significantly different between the left and right testis (337.6 months vs denotes not reached, p=0.001). The recurrence rate was significantly higher (84.7% vs 68.2%; p=0.002) in patients with right testicular tumour when compared to patients with left testicular tumour. Conclusion: The survival of the patients with tumour localized in the right testis was higher than patients with tumour localized in the left testis.