Dergiler / Veteriner Cerrahi Dergisi / 1997 / Cilt: 3 - Sayı: 2
A preliminary report chemotheraphy versus chemotheraphy plus immunotheraphy in the treatment of lymphosarcoma in the dog
- Sayfa
- 48–52
- DOI
- —
Özet
İ.Ü. Veteriner Fakültesi'nde 15 lenfosarkoma olgusu saptandı. Bunlardan 7 tanesine sağaltım uygulanmadı. Diğer 8 köpek 2 gruba ayrıldı. İlk gruptaki 4 köpeğe siklik kombinasyon kemoterapisi (L-asparaginase,vincristine, cyelophosphamide, methotrexate, prednisolon, adriamycin ve leukeran) uygulandı. İkinci gruptaki 4 köpeğe ise kombinasyon kemoterapi protokolü¬ne ilaveten alfa interferon ile iınınünoterapi uygulandı. Sağaltım uygulanmayan 7 köpeğin ortalama sağ kalım süresi 70.7 gün olurken, kemoterapi grubunda 225 gün olarak belirlendi. Kcmoterapiye ilaveten iınınünoterapi uygulanan grupta ise ortalama sağkalım süresi 591.3 gün oldu.
Abstract
Fifteen dogs with malignant lymphoma were presented at the Faculty of Veterinary Medicine of the University of Istanbul. 7 of the 15 dogs were not treated. Remaining 8 dogs were divided into two group. The first group consisted of 4 dogs and was treated with cyclic combination chemotherapy (L- asparaginase, vincristine, cyclophosplamidc, methotrexate, prednisolon, adriamycin and leukcran). 4 dogs of the second group were treated with the same combination chemotherapy protocol plus immunotherapy with alpha inter-feron. The mean survival time of the 7 untreated dogs was 70.7 days which compared with mean survival time of 225 days for the chemotherapy group. 4 dogs subjected to chemotherapy plus immunotherapy had a mean survival time of 591.3 doys.