A New Triterpene from Buddleja lindleyana with Neuroprotective Effect

Abstract

In the phytochemical investigation of Buddleja lindleyana, a new 3-acetyl substituted triterpene, 13, 28-epoxy-23-hydroxy-3β-acetoxy-olean-11-ene (1), together with four same skeleton type known compounds (25) were isolated. The structure of 1 was elucidated by means of extensive spectroscopic analysis. Their neuroprotective effect against 1-methyl-4 -phenylpyridinium ion-induced (MPP+-induced) neurotoxicity in SHSY5Y cells were evaluated. The structure activity relationship of compounds 1-5 has been discussed preliminarily