Dergiler / Records of Natural Products / 2018 / Cilt: 12 - Sayı: 2

Antileishmanial Activity of New ent--Kaurene Diterpene Glucoside Isolated from Leaves of Xylopia excellens R.E.Fr. (Annonaceae)

Daniella C.de ALENCAR,Felipe M.A DA SİLVA,Richardson A.de HELİTO VOLPADO,Livia M. DUTRA,Helito VOLPATO,Celso V NAKAMURA

Sayfa
190–200
DOI
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Abstract

This work describes a new ent-kaurene diterpene glucoside, 7?-O-?-D-glucopyranoside-ent-kaur-16ene, from the leaves of Xylopia excellens R.E.Fr. (Annonaceae). The compound showed high in vitro antileishmanial activity (IC50 of 15.23 ± 0.64 µg/mL) towards promastigote forms of Leishmania amazonensis, and low cytotoxicity against J774A1 cells (SI of 1.96).