Dergiler / Records of Natural Products / 2018 / Cilt: 12 - Sayı: 2

New Cytotoxic Pregnane-type Steroid from the Stem Bark of Aglaia elliptica (Meliaceae)

Kindi FARABİ,Desi HARNETİ,NURLELASARİ,Rani MAHARANİ,Ace Tatang HİDAYAT,Khalijah AWANG,Unang SUPRATMAN,Yoshihito SHİONO

Sayfa
121–146
DOI
—

Abstract

A new pregnane-type steroid, 2?-hydroxy-3?-methoxy-5?-pregnane (1), together with three known dammarane-type triterpenoid, 3?-acetyl-20S,24S-epoxy-25-hydroxydammarane (2), 20S,24S-epoxy-3?,25dihydroxydammarane (3), and eichlerianic acid (4) have been isolated from the stem bark of Aglaia elliptica. The structures were determined by spectroscopic methods including the 2D-NMR techniques. Compound 1-4 showed moderate cytotoxic activity against P-388 murine leukemia cells.

New Cytotoxic Pregnane-type Steroid from the Stem Bark of Aglaia elliptica (Meliaceae) — AJindex