Dergiler / Records of Natural Products / 2019 / Cilt: 13 - Sayı: 6

Two New Cholestanol Glycosides from the Roots and Rhizomes of Smilacina henryi

Xin ZHANG,Jing SUN,Shuo ZHANG,Yafeng YAN,Rongxin ZHANG,Xuanji XUE,Zengjun GUO

Sayfa
499–505
DOI
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Özet

Two new cholestanol glycosides (1 and 2) were obtained from the roots and rhizomes of Smilacina henryi. Their structures were determined as 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione 3-O-β-D-glucopyranosyl-(1→2)-β-D-galactopyranoside (1), 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione 3-O-β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-β-D-galactopyranoside (2), by physicochemical properties and spectroscopic methods. In addition, the isolated glycosides were tested for their cytotoxic activity against human HepG2 tumor cells and compound 2 showed moderate activity with IC50 value of 59.32 μM.